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Nitoxin is indicated for the treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica.
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✅ Description:
Nitazoxanide, Antiprotozoals is used to treat diarrhea caused by Giardia lamblia or Cryptosporidium parvum. Helps in treating diarrhea by regulating water absorption and secretion in the stool.
- This medicine may not be effective for treating diarrhea caused by C. parvum in HIV-infected or immunodeficient patients.
- Before taking Nitazoxanide, inform your doctor if you have kidney, liver, or biliary problems.
- Use Nitazoxanide with caution during pregnancy and breastfeeding, as safety data in these populations has not been established.
- Not recommended for use in children under 11 years of age. Use with caution in elderly patients above 65 years of age.
Follow your doctor's instructions carefully while taking Nitazoxanide and report any worsening of symptoms or unusual side effects promptly.
Safety Advices
Alcohol
UNSAFE
It is not known whether it is safe to consume alcohol with Nitoxin. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Nitoxin 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects on the developing baby; however, there are limited human studies.
Breastfeeding
SAFE IF PRESCRIBED
Nitoxin should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body. If you are taking Nitoxin, monitor the baby for diarrhea.
Driving
CAUTION
Nitoxin may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
There is limited information available on the use of Nitoxin in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Nitoxin in patients with liver disease. Please consult your doctor.
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✔️ Uses of Nitoxin 500
- Diarrhea
- Worm infections
✔️ How does Nitoxin 500 work?
Nitazoxanide, the active ingredient, inhibits the production of certain chemicals essential for the energy metabolism and growth of the parasite.
✔️ Side Effects of Nitoxin 500
Headache, nausea, fever, hair loss, vomiting, abnormal liver function tests, dizziness, abdominal pain, and vertigo.
✔️ Quick Suggestions:
- Take Nitoxin with food.
- Crush or chew the tablet if unable to swallow whole.
- Avoid during pregnancy or breastfeeding.
- Monitor blood counts and liver function during treatment.
- Finish the prescribed course even if symptoms improve.
✔️ Indication of Nitoxin 500
Nitoxin is an antiparasitic medication used in the treatment of diarrhea and worm infections. It inhibits the growth of the parasite, thus treating the infection.
✔️ Pharmacology
itazoxanide, the active ingredient in Nitoxin, is a synthetic antiprotozoal agent administered orally. It interferes with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependent electron transfer reaction, essential for the anaerobic energy metabolism of the protozoa. Nitazoxanide and its metabolites, nitazoxanide, inhibit the growth of sporozoites and oocysts of Cryptosporidium parvum and trophozoites of Giardia lamblia in vitro.
✔️ Dosage & Administration of Nitoxin 500
Adult Dose: Oral Giardiasis; Cryptosporidiosis Adult: 500 mg every 12 hr for 3 days.
Child Dose: Oral Giardiasis; Cryptosporidiosis Child: 1-3 yr: 100 mg(5 ml) every 12 hr; 4-11 yr: 200 mg(10ml) every 12 hr; >12 yr: 500 mg every 12 hr. All doses are to be taken for 3 days.
Take Nitoxin as directed by your doctor, swallow it whole with food, and do not chew or crush it
✔️ Interaction
Nitoxin may interact with other drugs highly bound to plasma proteins. Caution is advised when administering Nitoxin concurrently with such drugs, especially those with a narrow therapeutic index.
✔️ Contraindications
Hypersensitivity.
✔️ Pregnancy & Lactation
Nitazoxanide is classified as US FDA pregnancy category B. While there are limited studies in pregnant women, caution should be exercised, and Nitazoxanide should be used during pregnancy only if needed. Nitazoxanide is excreted in human milk, so caution is also advised during lactation.
✔️ Precautions & Warnings
- Nitoxin should be used with caution in patients with hepatic & biliary disease and renal disease.
- Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr.
✔️ Storage Conditions:
Store Nitoxin in a dry place away from light and heat, and keep it out of the reach of children.
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